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Biblioteca (s) : |
INIA Treinta y Tres. |
Fecha : |
17/04/2017 |
Actualizado : |
11/10/2019 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
LAKIN, S.M.; DEAN, C.; NOYES, N.R.; DETTENWANGER, A.; ROSS, A. S.; DOSTER, E.; ROVIRA, P.J.; ABDO, Z.; JONES, K.L.; RUIZ, J.; BELK, K.E.; MORLEY, P.S.; BOUCHER, C. |
Afiliación : |
STEVEN M. LAKIN; CHRIS DEAN; NOELLE R. NOYES; ADAM DETTENWANGER; ANNE SPENCER ROSS; ENRIQUE DOSTER; PABLO JUAN ROVIRA SANZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. Department of Animal Sciences, Colorado State University, USA.; ZAID ABDO; KENNETH L. JONES; JAIME RUIZ; KEITH E. BELK; PAUL S. MORLEY; CHRISTINA BOUCHER. |
Título : |
MEGARes: an antimicrobial resistance database for high throughput sequencing. |
Fecha de publicación : |
2017 |
Fuente / Imprenta : |
Nucleic Acids Research, 2017 v.45 p.574-580. |
DOI : |
10.1093/nar/gkw1009 |
Idioma : |
Inglés |
Notas : |
Article History: Published online 2016 Nov 24.
DOI: https://doi.org/10.1093/nar/gkw1009 |
Contenido : |
Antimicrobial resistance has become an imminent concern for public health. As methods for detection and characterization of antimicrobial resistance move from targeted culture and polymerase chain reaction to high throughput metagenomics, appropriate resources for the analysis of large-scale data are required. Currently, antimicrobial resistance databases are tailored to smaller-scale, functional profiling of genes using highly descriptive annotations. Such characteristics do not facilitate the analysis of large-scale, ecological sequence datasets such as those produced with the use of metagenomics for surveillance. In order to overcome these limitations, we present MEGARes (https://megares.meglab.org), a hand-curated antimicrobial resistance database and annotation structure that provides a foundation for the development of high throughput acyclical classifiers and hierarchical statistical analysis of big data. MEGARes can be browsed as a stand-alone resource through the website or can be easily integrated into sequence analysis pipelines through download. Also via the website, we provide documentation for AmrPlusPlus, a user-friendly Galaxy pipeline for the analysis of high throughput sequencing data that is pre-packaged for use with the MEGARes database. |
Palabras claves : |
BASE DE DATOS; BIOINFORMÁTICA; DATASETS; DRUG RESISTANCE; GENES; METAGENÓMICA; METAGENOMICS; MICROBIAL; POLYMERASE CHAIN REACTION; PUBLIC HEALTH MEDICINE; RESISTENCIA ANTIMICROBIANA; SEQUENCE ANALYSIS. |
Asunto categoría : |
L01 Ganadería |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/6677/1/Rovira-arb-2017-1.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210519/
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Marc : |
LEADER 02505naa a2200433 a 4500 001 1057051 005 2019-10-11 008 2017 bl uuuu u00u1 u #d 024 7 $a10.1093/nar/gkw1009$2DOI 100 1 $aLAKIN, S.M. 245 $aMEGARes$ban antimicrobial resistance database for high throughput sequencing.$h[electronic resource] 260 $c2017 500 $aArticle History: Published online 2016 Nov 24. DOI: https://doi.org/10.1093/nar/gkw1009 520 $aAntimicrobial resistance has become an imminent concern for public health. As methods for detection and characterization of antimicrobial resistance move from targeted culture and polymerase chain reaction to high throughput metagenomics, appropriate resources for the analysis of large-scale data are required. Currently, antimicrobial resistance databases are tailored to smaller-scale, functional profiling of genes using highly descriptive annotations. Such characteristics do not facilitate the analysis of large-scale, ecological sequence datasets such as those produced with the use of metagenomics for surveillance. In order to overcome these limitations, we present MEGARes (https://megares.meglab.org), a hand-curated antimicrobial resistance database and annotation structure that provides a foundation for the development of high throughput acyclical classifiers and hierarchical statistical analysis of big data. MEGARes can be browsed as a stand-alone resource through the website or can be easily integrated into sequence analysis pipelines through download. Also via the website, we provide documentation for AmrPlusPlus, a user-friendly Galaxy pipeline for the analysis of high throughput sequencing data that is pre-packaged for use with the MEGARes database. 653 $aBASE DE DATOS 653 $aBIOINFORMÁTICA 653 $aDATASETS 653 $aDRUG RESISTANCE 653 $aGENES 653 $aMETAGENÓMICA 653 $aMETAGENOMICS 653 $aMICROBIAL 653 $aPOLYMERASE CHAIN REACTION 653 $aPUBLIC HEALTH MEDICINE 653 $aRESISTENCIA ANTIMICROBIANA 653 $aSEQUENCE ANALYSIS 700 1 $aDEAN, C. 700 1 $aNOYES, N.R. 700 1 $aDETTENWANGER, A. 700 1 $aROSS, A. S. 700 1 $aDOSTER, E. 700 1 $aROVIRA, P.J. 700 1 $aABDO, Z. 700 1 $aJONES, K.L. 700 1 $aRUIZ, J. 700 1 $aBELK, K.E. 700 1 $aMORLEY, P.S. 700 1 $aBOUCHER, C. 773 $tNucleic Acids Research, 2017$gv.45 p.574-580.
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INIA Treinta y Tres (TT) |
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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
Fecha actual : |
05/06/2019 |
Actualizado : |
09/10/2019 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Circulación / Nivel : |
Internacional - -- |
Autor : |
COSTA, R.A. DA; SCHILD, C.; CAFFARENA, D.; GIANNITTI, F.; BANCHERO, G.; DEL PINO, M.L.; RIET-CORREA, F. |
Afiliación : |
RICARDO ALMEIDA DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS SCHILD, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RUBEN DARÍO CAFFARENA LEDESMA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GEORGGET ELIZABETH BANCHERO HUNZIKER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARIA LILIANA DEL PINO BALADON, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
High frequency of cutaneous squamous cell carcinoma in Friesian Milchschaf sheep in Uruguay. [Alta frequência de carcinoma cutâneo de células escamosas em ovinos da raça Frisona Milchschaf no Uruguai]. |
Fecha de publicación : |
2019 |
Fuente / Imprenta : |
Pesquisa Veterinaria Brasileira, 1 January 2019, Volume 39, Issue 4, Pages 251-254. [Open Access]. |
ISSN : |
Print version 0100-736X /On-line version 1678-5150. |
DOI : |
10.1590/1678-5150-PVB-6170 |
Idioma : |
Inglés |
Notas : |
Article history: Received on December 3, 2018.//Accepted for publication on December 12, 2018. |
Contenido : |
ABSTRACT:This study described five cases of squamous cell carcinoma (SCC) in the pinnae, eyelids, and eyes of Friesian Milchschaf sheep from two flocks raised under extensive conditions in Uruguay. The prevalence values for both flocks were 2.12% and 2.53%, respectively. Macroscopically, single or multiple, nodular, verrucous, or plaque-like neoplasms, with occasional ulceration and bleeding, were observed in the affected areas. Histologically, well- and moderately-differentiated SCCs were diagnosed in three and two cases, respectively. The Milchschaf breed is native of Germany, and its individuals present white non-pigmented skin with the face and legs clear of fleece, thus adapted to areas with lower solar radiation. Additionally, in the German breeding systems, animals remain indoors for long periods. The increased exposure time to higher levels of solar radiation of the Uruguayan extensive production systems may be a predisposing factor for the development of SCC in this sheep breed. In Uruguay, there is more solar radiation and the production systems provide less protection against sunlight compared with the German production system. The high frequency of SCC should be considered prior to introducing European breeds with non-pigmented skin in Uruguay and other countries of the region.
RESUMO:Descreveram-se carcinomas de células escamosas (CCE) nas orelhas, pálpebras e olhos em cinco ovinos da raça Frisona Milchschaf em dois rebanhos de criação extensiva no Uruguai. A prevalência nos rebanhos foi de 2,12% e 2,53%. Macroscopicamente se observaram lesões focais ou multifocais, com aumento de volume, nodulares, verrucosas ou em placas, com ocasionais ulcerações e hemorragias. Apresentavam aspecto verrucoso, por vezes com superfície ulcerada e firmes ao corte. De acordo com as características histológicas da neoplasia, as lesões foram classificadas em CCEs bem diferenciados em três casos e moderadamente diferenciados em dois casos. Esta raça é nativa da Alemanha, caracterizada pela face deslanada e pele branca despigmentada. Na Alemanha, há menores níveis de radiação solar do que no Uruguai e seu sistema de produção é mais intensivo, com permanência dos animais confinados durante longos períodos. O aumento do tempo de exposição a níveis mais elevados de radiação solar pode ser um fator predisponente para o desenvolvimento de CCEs nesta raça em sistemas extensivos de produção no Uruguai. Neste País há mais radiação solar e os sistemas produtivos fornecem menos proteção contra a luz solar, em relação ao sistema de produção alemão. A alta frequência de CEE deveria ser levada em consideração para quem decide introduzir no Uruguai e outros países da região. raças europeias com a face despigmentada MenosABSTRACT:This study described five cases of squamous cell carcinoma (SCC) in the pinnae, eyelids, and eyes of Friesian Milchschaf sheep from two flocks raised under extensive conditions in Uruguay. The prevalence values for both flocks were 2.12% and 2.53%, respectively. Macroscopically, single or multiple, nodular, verrucous, or plaque-like neoplasms, with occasional ulceration and bleeding, were observed in the affected areas. Histologically, well- and moderately-differentiated SCCs were diagnosed in three and two cases, respectively. The Milchschaf breed is native of Germany, and its individuals present white non-pigmented skin with the face and legs clear of fleece, thus adapted to areas with lower solar radiation. Additionally, in the German breeding systems, animals remain indoors for long periods. The increased exposure time to higher levels of solar radiation of the Uruguayan extensive production systems may be a predisposing factor for the development of SCC in this sheep breed. In Uruguay, there is more solar radiation and the production systems provide less protection against sunlight compared with the German production system. The high frequency of SCC should be considered prior to introducing European breeds with non-pigmented skin in Uruguay and other countries of the region.
RESUMO:Descreveram-se carcinomas de células escamosas (CCE) nas orelhas, pálpebras e olhos em cinco ovinos da raça Frisona Milchschaf em dois rebanhos de criação extensiva no Uruguai. A p... Presentar Todo |
Palabras claves : |
CUTANEOUS CARCINOMA; DERMATOPATHOLOGY; ENFERMEDADES DE LAS OVEJAS; FRIESIAN MILCHSCHAF; NEOPLASM; PATHOLOGY; PLATAFORMA SALUD ANIMAL; SALUD ANIMAL; SHEEP; SHEEP DISEASES; SKIN DISEASES; SQUAMOUS CELL CARCINOMA; TUMORS. |
Thesagro : |
ENFERMEDADES DE LOS ANIMALES; OVEJA; URUGUAY. |
Asunto categoría : |
L73 Enfermedades de los animales |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/12748/1/Pesq.-Vet.-Bras.-394-251-254-April-2019.pdf
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Marc : |
LEADER 04254naa a2200421 a 4500 001 1059813 005 2019-10-09 008 2019 bl uuuu u00u1 u #d 022 $aPrint version 0100-736X /On-line version 1678-5150. 024 7 $a10.1590/1678-5150-PVB-6170$2DOI 100 1 $aCOSTA, R.A. DA 245 $aHigh frequency of cutaneous squamous cell carcinoma in Friesian Milchschaf sheep in Uruguay. [Alta frequência de carcinoma cutâneo de células escamosas em ovinos da raça Frisona Milchschaf no Uruguai].$h[electronic resource] 260 $c2019 500 $aArticle history: Received on December 3, 2018.//Accepted for publication on December 12, 2018. 520 $aABSTRACT:This study described five cases of squamous cell carcinoma (SCC) in the pinnae, eyelids, and eyes of Friesian Milchschaf sheep from two flocks raised under extensive conditions in Uruguay. The prevalence values for both flocks were 2.12% and 2.53%, respectively. Macroscopically, single or multiple, nodular, verrucous, or plaque-like neoplasms, with occasional ulceration and bleeding, were observed in the affected areas. Histologically, well- and moderately-differentiated SCCs were diagnosed in three and two cases, respectively. The Milchschaf breed is native of Germany, and its individuals present white non-pigmented skin with the face and legs clear of fleece, thus adapted to areas with lower solar radiation. Additionally, in the German breeding systems, animals remain indoors for long periods. The increased exposure time to higher levels of solar radiation of the Uruguayan extensive production systems may be a predisposing factor for the development of SCC in this sheep breed. In Uruguay, there is more solar radiation and the production systems provide less protection against sunlight compared with the German production system. The high frequency of SCC should be considered prior to introducing European breeds with non-pigmented skin in Uruguay and other countries of the region. RESUMO:Descreveram-se carcinomas de células escamosas (CCE) nas orelhas, pálpebras e olhos em cinco ovinos da raça Frisona Milchschaf em dois rebanhos de criação extensiva no Uruguai. A prevalência nos rebanhos foi de 2,12% e 2,53%. Macroscopicamente se observaram lesões focais ou multifocais, com aumento de volume, nodulares, verrucosas ou em placas, com ocasionais ulcerações e hemorragias. Apresentavam aspecto verrucoso, por vezes com superfície ulcerada e firmes ao corte. De acordo com as características histológicas da neoplasia, as lesões foram classificadas em CCEs bem diferenciados em três casos e moderadamente diferenciados em dois casos. Esta raça é nativa da Alemanha, caracterizada pela face deslanada e pele branca despigmentada. Na Alemanha, há menores níveis de radiação solar do que no Uruguai e seu sistema de produção é mais intensivo, com permanência dos animais confinados durante longos períodos. O aumento do tempo de exposição a níveis mais elevados de radiação solar pode ser um fator predisponente para o desenvolvimento de CCEs nesta raça em sistemas extensivos de produção no Uruguai. Neste País há mais radiação solar e os sistemas produtivos fornecem menos proteção contra a luz solar, em relação ao sistema de produção alemão. A alta frequência de CEE deveria ser levada em consideração para quem decide introduzir no Uruguai e outros países da região. raças europeias com a face despigmentada 650 $aENFERMEDADES DE LOS ANIMALES 650 $aOVEJA 650 $aURUGUAY 653 $aCUTANEOUS CARCINOMA 653 $aDERMATOPATHOLOGY 653 $aENFERMEDADES DE LAS OVEJAS 653 $aFRIESIAN MILCHSCHAF 653 $aNEOPLASM 653 $aPATHOLOGY 653 $aPLATAFORMA SALUD ANIMAL 653 $aSALUD ANIMAL 653 $aSHEEP 653 $aSHEEP DISEASES 653 $aSKIN DISEASES 653 $aSQUAMOUS CELL CARCINOMA 653 $aTUMORS 700 1 $aSCHILD, C. 700 1 $aCAFFARENA, D. 700 1 $aGIANNITTI, F. 700 1 $aBANCHERO, G. 700 1 $aDEL PINO, M.L. 700 1 $aRIET-CORREA, F. 773 $tPesquisa Veterinaria Brasileira, 1 January 2019, Volume 39, Issue 4, Pages 251-254. [Open Access].
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